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REDEFINE 1: CagriSema in overweight or obesity, NEJM full text REDEFINE 1: PubMed 40544433 REDEFINE 2: CagriSema in type 2 diabetes and obesity, NEJM full text REDEFINE 2: PubMed 40544432 Phase 1b: cagrilintide co-administered with semaglutide 2.4 mg, The Lancet (2021) Phase 2: once-weekly cagrilintide dose-finding, The Lancet (2021) REDEFINE 1 trial record: NCT05567796 Phase 2 trial record: NCT03856047 Phase 1b trial record: NCT03600480 Novo Nordisk files for FDA approval of CagriSema: press release (Dec 2025) CagriSema regulatory history: Drugs.com The 0.25 → 2.4 mg four-week ladder is stated explicitly in both NEJM papers, for the fixed-dose combination pen

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The initial management of overdose: After a careful clinical evaluation of the patient the importance of time elapsed since last ingestion or administration, the amount of poison swallowed and discarding the contraindication of certain procedures, the professional will decide whether or not the treatment of general rescue: emesis or gastric lavage, activated charcoal and saline purgative (45 to 60 minutes after the activated carbon), hemodialysis