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(63) studying the long-term effects (more than 24 weeks) of increasing omega-3, omega-6, and total PUFA on IBD outcomes (including induced relapse or remission) and various markers of inflammation concluded that high intakes of long-chained n-3 fatty acids might reduce risk of IBD relapse, IBD worsening, and reduce the erythrocyte sedimentation rate, which together with C-reactive protein is a biomarker for systemic inflammation and a non-specific indicator of IBD

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These medications illustrate the core tension running through longevity medicine: they are prescription drugs with FDA approval for specific, well-established conditions, but their use in healthy-aging contexts represents off-label prescribing grounded in research interest rather than proven longevity outcomes in humans