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The cytokines secreted by Th1 and Th17 cells (e.g., IFN-γ and IL-17) can directly act on hepatic stellate cells, stimulating their activation and proliferation, which leads to the synthesis of extracellular matrix components like collagen and contributes to liver fibrosis [101, 102]

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10.21276/apjhs.2022.9.1.03 272

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