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The specific residues of proteins involved in lipid binding (FABP) are particularly sensitive to impairment of function by 4-HNE and consequently may lead to impaired metabolic homeostasis

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Treatment with CagriSema 2.4 mg OW SC resulted in an average 15.6% reduction in body weight, which was superior to the weight loss observed with cagrilintide 2.4 mg (8.1%) alone or semaglutide 2.4 mg (5.1%) alone [124]