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Ideal Candidate Profile Research suggests the best candidates for gel injections include: Mild to moderate knee osteoarthritis (Kellgren-Lawrence grades 2-3) Patients who have failed conservative treatments (physical therapy, NSAIDs, weight management) Those seeking to delay or avoid knee replacement surgery Patients with contraindications to NSAIDs or steroid injections Active individuals seeking to maintain mobility and function Comparison with Alternative Injection Therapies Cortisone (Corticosteroid) Injections Cortisone shots tend to work faster than HA injections, often within a few days, but the benefits are not as long-lasting with most patients starting to feel pain again in 2 to 3 months [9]
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A proposed mechanism of action representing TP4 action and its significant events are depicted in Figure 12
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