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Among the key players in iron homeostasis, solute carrier family 40 member 1 (SLC40A1, also known as ferroportin) is the only known iron exporter in mammals, pivotal for orchestrating cellular iron dynamics in ferroptotic pancreatic cancer cells [104]

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The renoprotective effect of FXR is mainly mediated by regulating lipid metabolism, oxidative stress, pro-inflammatory cytokines, and pro-fibrotic factors, thus inhibiting the increased proteinuria, podocyte loss, mesangial expansion and renal lipid accumulation (Masaoutis and Theocharis, 2019)