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In the SURMOUNT-5 head-to-head comparison with semaglutide, tirzepatide produced approximately 20% greater body weight reduction, establishing it as the more potent weight loss agent currently available.[5] PCOS-specific RCT data for tirzepatide is less mature than for semaglutide — no large completed trials in PCOS populations exist as of early 2026 — but the mechanistic case is compelling
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