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Crystal structure of a SIR2 homolog-NAD complex [PMID: 11336676] Laboratory literature summary: Crystal structure of a SIR2 homolog-NAD complex
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This heightens susceptibility to the toxic effects of iron overload, disrupting intestinal mucosal homeostasis and triggering local inflammation and cell death, ultimately precipitating the onset of gut-associated diseases ( 2.2 Iron overload, deficiency, and IBD pathogenesis In the intestinal microenvironment of IBD, iron overload or functional iron deficiency not only serves as a source of oxidative stress but also acts as a critical factor triggering ferroptosis in intestinal epithelial cells
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