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However, the significance of this effect is unclear as the authors did not include comparator groups without dextran sulfate sodium treatment, which would be needed meaningfully assess the effect of the treatment on circadian rhythmicity
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Early intervention with senomorphic compounds could delay the onset of age-related diseases by modulating senescence in at-risk individuals, potentially leading to an extension of healthspan (the period of life spent in good health).35,130 This preventive approach could be especially beneficial for populations with genetic predispositions to certain conditions or those already showing early signs of aging-related decline
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