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The intrinsic apoptosis pathway is orchestrated by the Bcl-2 protein family, which comprises three functional subgroups: pro-apoptotic proteins (BAX, BAK, and BOK), anti-apoptotic proteins (BCL-2, BCL-XL, and MCL-1), and BH3-only proteins (BIM, PUMA, and tBID)
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[DOI] [PubMed] [Google Scholar] Lopez-Arrabe J, Monaghan P, Cantarero A, Boner W, Perez-Rodriguez L, Moreno J