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Under hypoxic conditions, HIF-1α expression is elevated and activates the BMP4/SMAD pathway, enhancing the expression of osteogenic markers such as OCN and OPN, and thereby promoting osteogenic differentiation of BMSCs (Zhang J
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By contrast, no universally accepted executioner protein has yet been identified for ferroptosis, raising the question of how lipid peroxidation is translated into terminal membrane failure
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