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and a 16- week randomized clinical trial) and in HIV-patients (a 20- week open label trial published Sept 2020) showed that compared to young controls (for elderly human trials) and non-HIV controls (for the HIV clinical trial), elderly humans and HIV patients had severely elevated inflammation (plasma IL-6, CRP and TNF-alpha), endothelial dysfunction (plasma sICAMl, sVCAMl and E- selectin), insulin resistance, genomic damage, impaired autophagy, mitophagy and mitochondrial function and energy regulation, and with muscle weakness, poor exercise capacity and cognitive impairment

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Male rats were used in order to minimize the variability of behavior in estrous cycling during Morris water maze testing and to match arsenic neurotoxicity paradigms that are commonly employed in adult rodents