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Progesterone receptor modulator-associated endometrial changes (PAEC) have been found to occur in 0.4% of patients using UPA while 41%–78.8% of patients who developed PAEC appeared to be reversible upon discontinuing UPA (De Milliano et al., 2017)
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Across human macrophage models and rodent LPS-challenge systems, sulforaphane-mediated Nrf2 activation reduces intracellular reactive oxygen species, attenuates NF-κB signaling, and lowers pro-inflammatory cytokine release, including TNF-α and IL-6 (Yan and Yan, 2023
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