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To address these challenges, various delivery methods have been investigated, including viral vectors, non-viral vectors, and rational design strategies such as chemical modifications, cationic liposomes, polymers, nanocarriers, and biocoupled siRNAs, aimed at enhancing stability and intracellular delivery (Yu et al., 2020)
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NNMT-expressing GSCs contain lower levels of methionine, SAM, NAM, and higher levels of SAH, 1-MNAM, as well as NAD + unexpectedly